Human immunodeficiency virus bellarmine university. Oct 26, 2012 pathogenesis of hiv raja zahidah binti raja ismail anis nabila binti md nor farina binti nor hashimi muhammad fattah bin fazel slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Introduction to hiv, aids and sexually transmitted infection. Molecular virology of hiv1 and current antiviral strategies paul a. It also serves as a good reference to parasitologists, graduate students, biomedical personnel, and health professionals. Pakistan, afghanistan and nigeria are endemic to poliovirus. Biol 4703 exams will be detailed and comprehensive. This is discussed alongside the role of granulomatous in. Because an hiv regimen includes hiv medicines from at least two different hiv drug classes, art is very effective at preventing hiv from multiplying. Hiv1 strains emerge at the advanced disease stage only. Over the past three decades of intense research on the contribution of viral and host factors determining the variability in hiv1 infection outcome, hiv pathogenesis is still a fascinating topic that requires further study. A greater understanding of the pathogenesis of hiv disease is providing us. Pdf pathogenesis studies of hivaids, a general viral topic. Each class of drugs is designed to target a specific step in the hiv life cycle.
Free virology books download ebooks online textbooks tutorials. There is an initial period of influenzalike illness, and then a latent, asymptomatic phase. Level of prevention is primary, and mode of interventionhealth promotion and specific protection pathogenesis stage. Introduction the field of antiretroviral therapy has been explosive over the past 17 years as hiv targets have been identified, drugs developed and pathogenesis unraveled. The most important factor that increases the risk of sexual transmission of hiv1 is the number of copies per ml of plasma hiv1 rna viral load, with a 24 times increased risk of sexual transmission for every 1 log 10 increase. This booklet aims to help you understand hivaids more clearly by. Jun 15, 2017 of the 3 strains of wild poliovirus type 1, type 2, and type 3, wild poliovirus type 2 was eradicated in 1999 and no case of wild poliovirus type 3 has been found since the last reported case in nigeria in november 2012. This lecture note is useful to students of health science, medicine and other students and academicians. An understanding of the exact mechanism of how these factors influencing.
Hivaids epidemiology, pathogenesis, prevention, and treatment. The human immunodeficiency viruses 1 and 2 hiv1, hiv2 originated from the simian immunodeficiency viruses sivs of primates. Hiv virology and pathogenetic mechanisms of infection. Lecture notes of epidemiology february 14, 2019 ebooks md this book is written with the intention of sharing the basic knowledge of epidemiology with undergraduate students, academicians, medical health practitioners and allied health professionals. Free virology books download ebooks online textbooks. Updated annually by kaplans allstar faculty integrated. In 1983, the human immunodeficiency virus hiv responsible for aids was first isolated. National reference laboratory stdaids cooperative central laboratory hiv is the virus that causes aids.
Over the past three decades of intense research on the contribution of viral and host factors determining the variability in hiv1 infection outcome, hiv. Introduction to hiv, aids and sexually transmitted. On a macroscopic level there are the mechanisms by which the tuberculous bacilli disseminate to the cns. Acquired immune deficiency syndrome aids is caused by the hiv or human immunodeficiency virus. Introduction to hiv, aids and sexually transmitted infection surveillance. Many individuals believe hiv does not exist, condoms do not work, that only certain people are at risk of hiv infection, that hiv cannot be treated, that there is a cure or that you can become infected through food, water, toilets, showers and pools etc. Hiv and the intricate relationship between viral pathogenesis and immune defenses.
The course will emphasize the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. Proportion of hiv attributed tuberculosis cases in the world estimates for 1990, 1995, 2000. Molecular virology of hiv1 and current antiviral strategies. Hiv1 was first isolated in 1983 and hiv2 in 1986 and they represent two different epidemics. An understanding of the exact mechanism of how these factors influencing hiv pathogenesis is critical to the development of effective strategies to prevent infection. N haramaya university in collaboration with the ethiopia public health training initiative, the carter center, the. It has been theorized that the virus originated from monkeys during the. May 01, 2020 the origin and development of a disease. Every step in viral life cycle is a potential antiviral target. More than two thousand million 2 billion people alive today have been infected with the hepatitis b virus.
As intracellular parasites, all viruses must be intimately familiar with host cellular machinery and capable of suborning it to support their replication cycle. Introduction to hivaids origin, theories and history of the pandemic the origin of. Proportion of hivattributed tuberculosis cases in the world estimates for 1990, 1995, 2000 0,315 0,739 1,418 1,1 7,5 8,8 10,2 7,6 0 2 4 6 8 10 12 14 1990 1995 2000 2011. Thus, hiv1 and hiv2 each had a zoonotic origin but now spread directly from human to human. However, access to antiretroviral therapy is much lower in children than adults. Regional office for the eastern mediterranean introduction to hiv, aids and sexually transmitted infection surveillance. Upon acquisition of the virus, the virus replicates inside and kills t helper cells, which are required for almost all adaptive immune responses. Lecture notes undergraduate nursing students pathophysiology fuad ibrahim md mengistu welday m. This columbia university virology course is offered each year in the spring semester. A summary of all these studies supports increased turnover. The central question of hiv1 pathogenesis is through what. Perspectives on progress in plant virology pdf 21p this note describes the following topics. The early events of hiv infection are likely to be important to the later course of the. Hiv pathogenesis involves depletion of t cells, possibly by.
Pathophysiology of hiv baylor international pediatrics aids initiative. It is important to distinguish between hiv and aids. Approximately 350 million are chronically infected and are at high risk of serious illness and death from cirrhosis of. Hiv is a member of the lentivirus family, a subgroup of retroviruses, rna viruses that replicate via a dna intermediate. Hiv introduction acquired immune deficiency syndrome aids was first identified in 1981in a small group of gay men in the san francisco area who presented with unusual opportunistic infections. Pathophysiology pdf notes pathophysiology pdf notes download. Hiv attacks immune cells and is transmitted through bodily fluids. Jul 01, 2019 hiv attacks and destroys the cd4 cells of the immune system. The molecular basis of alternative reproductive cycles, the interactions of viruses with host organisms, and how these lead to disease are presented with examples. Hiv my lecture notes introduction to hiv\aids origin. Contents concept of health and disease infectious disease epidemiology disease prevention and control disease screening epidemics investigation nb. Increasing data suggest that shortcourse antiretroviral therapy started in. Pathogenesis a discussion on the pathogenesis of tuberculous meningitis can be directed on two levels. Stages of hiv 1 infection short, flulike illness occurs one to six weeks after infection no symptoms, infected person can infect other people asymptomaticup to ten years no symptoms, may be swollen glands, hiv level is very low, hiv antibodies are detectable symptomatic the symptoms are mild the immune system.
National reference laboratory stdaids cooperative central laboratory hiv aids 2. Th1 and th2 cytokines play an important role in the pathogenesis of hiv infection and development of aids. Pathology april 22, 2019 ebooks md the only official kaplan lecture notes for usmle step 1 cover the comprehensive information you need to ace the exam and match into the residency of your choice. The human immunodeficiency viruses 1 and 2 hiv 1, hiv 2 originated from the simian immunodeficiency viruses sivs of primates.
The disease was first reported from wuhan, china and has since then, spread globally, causing the 20192020 pandemic. Proteins, nucleic acids, serology, replication of plant viruses in vectors, insect tissue cultures as a tool for studying plant viruses, virusinduced mutations in maize, noncapsid viral proteins, viruses infecting eukaryotic chlorellalike green algae, application of recombinant dna. Embed in courseown notes embed lecture the pathogenesis of tuberculosis dr. It attacks the immune system the bodys defense against disease. Earlier in the course of infection, many hiv infected persons have a syndrome of. Douek indicated that there are many factors that contribute to the pathogenesis in hiv infection. This raises another major paradox in hiv pathogenesis about the source of x4. In individuals infected with hiv, the normal th1 response to viral infection is shifted to th2 response.
It is believed to provide basic knowledge to students on medical parasitology. Aids is a condition that can arise from an advanced stage of infection with hiv. What happens is that you are in contact with somebody with open pulmonary tuberculosis and what we mean by open pulmonary tuberculosis is that if you look at the patients sputum you will see the bacteria present when you stain it with a special stain called acid fast bacili stain, so the sputum afb positive is the description. Studies on hiv virology and pathogenesis address the complex mechanisms that result. Hiv uses the machinery of the cd4 cells to multiply and spread throughout the body. The pathogenesis of hiv is basically a struggle between.
Bishai kwazulunatal research institute for tuberculosis and hiv, south africa and johns hopkins university center for tuberculosis research, usa. Surveillance of hiv risk behaviours world health organization. The global epidemiology of hiv infection has changed markedly. Thus, hiv 1 and hiv 2 each had a zoonotic origin but now spread directly from human to human. View notes hiv my lecture notes from hiv 001 at university of eastern africa, baraton.
Hepatitis a, b, and c, all of which can be sexually transmitted, are covered in the gi section of the course. They will be a combination of multiple choice, draw a picture, write an essay, fill in the blanks. An estimated 386 334460 million people live with hiv1 worldwide, while about 25 million have died already. Nov 29, 2018 hiv attacks immune cells and is transmitted through bodily fluids. This book by celebrated scientist jay levy is considered as the best book ever written about hiv and its pathogenesis as can be seen from the popularity of the book among students and professors. Pathogenesis of hiventering the information slide 3.
The only official kaplan lecture notes for usmle step 1 cover the comprehensive information you need to ace the exam and match into the residency of your choice. Coronavirus disease 2019 covid19 is an infectious respiratory tract infection caused by sarscov2. Cd4 cells are a type of white blood cell that play a major role in protecting the body from infection. Pathogenesis of cancer in hiv many are virallyinduced cancers, but not all immune activation, inflammation and decreased immune surveillance hiv may activate cellular genes or protooncogenes or inhibit tumor suppressor genes hiv induces genetic instability e. This raises another major paradox in hiv pathogenesis about the. Regional office for the eastern mediterranean, joint united nations programme on hiv aids p.
Mar 27, 2012 virology biology w3310 vincent racaniello, ph. Tb is spread from person to person through the air. Hiv hides attachment site cd4 long and slender visible effects of viral infection cytopathic effects 1. Pathogenesis of hiv raja zahidah binti raja ismail anis nabila binti md nor farina binti nor hashimi muhammad fattah bin fazel 2. Chapter 2 transmission and pathogenesis of tuberculosis. It does not in any way replace your lectures, class notes, textbooks or other learning materials. Balance between host defense mechanisms and virulence of mtb tips in favor of mtb organism due to mechanisms not yet clear, cellular immune response no longer able to contain mtb organisms proliferation and spread of organism, tissue destruction resulting in clinically evident disease. Pdf on mar 30, 2017, da yong lu and others published pathogenesis studies of hivaids, a general viral topic find, read and cite all the research you need on researchgate. This process, which is carried out in seven steps or stages, is called the hiv life cycle. If you are going to prepare a seminar you can compare with multiple similar presentations given here, some times if you are busy you can use these slides as such without any modification or with slight modification. Tuberculosis pathogenesis online learning with lecturio. Hiv 1 was first isolated in 1983 and hiv 2 in 1986 and they represent two different epidemics.
Regional office for the eastern mediterranean, joint united nations programme on hivaids p. It is written in a lecture note format for easy understanding and as a guide to improve the understanding of epidemiology. Packed with clinical correlations and bridges between disciplines. Stages of hiv1 infection short, flulike illness occurs one to six weeks after infection no symptoms, infected person can infect other people asymptomaticup to ten years no symptoms, may be swollen glands, hiv level is very low, hiv antibodies are detectable symptomatic the symptoms are mild the immune system. Pathogenesis includes the specific processes that occur during the development of a disease. Hiv medicines are grouped into different drug classes according to how they fight hiv. The dots in the air represent droplet nuclei containing tubercle bacilli. Overview of hiv infection 2 participant manual 2005 what is hiv. Pathophysiology pdf notes this pathophysiology lecture note will serve as a theoretical guideline for panasonic ag hvx200 pdf undergraduate. The human immunodeficiency virus hiv is a retrovirus belonging to the family of.
Transmission occurs when a person inhales droplet nuclei containing. I bought this book as a reference guide for my wife who is finding her phd in hiv pathogenesis and role of heat shock proteins in hiv progression. Acquired immune deficiency syndrome aids caused by human immunodeficiency virus hiv occurs world wide, causing the great pandemic of the second half of the twentieth century retrovirus theories on origin of disease hiv1 evolved from chimp virus sivcpz use of human blood products in chimps infected animals with hiv1 precursor. It is important to note that these trials will collect data on drug.
Lythgo over 40 million people are currently infected with the human immunodeficiency virus hiv, and over 25 million deaths have been attributed to the virus since the beginning of the epidemic. The basic thesis of the course is that all viruses adopt a common strategy. This file contains typed pathology notes from goljan audio. Significant progress has been made in identifying the role of ccr5 r5 and cxcr4 x4 hiv strains in disease progression. Aids is defined by a loss of cd4 t lymphocytes or the occurrence of opportunistic infections or cancers. Hiv is commonly transmitted via unprotected sexual activity, blood transfusions, hypodermic needles, and from mother to child. Introduction to hiv aids origin, theories and history of the pandemic the origin of aids and hiv has puzzled. Goljan pathology lecture notes typed pathology notes pdf. Hiv vaccine designed to prevent hiv transmission or slow the course of disease in. And in the chronic phase of infection, there is significant immune activation. The infection causes progressive destruction of the cellmediated immune cmi system, primarily by. Despite the frequent absence of symptoms during early and chronic phase, hiv1 replication is dynamic throughout the disease. Jun 06, 20 the interactions among chemokine receptors, chemokines, and hiv are likely to be critical to the pathogenesis of hiv disease. The viral stds hsv and hpv are included here so that we can discuss all the major stds, but they are covered in more detail elsewhere.
1300 677 149 1121 575 1405 1014 615 1095 718 379 716 727 1105 488 359 729 1613 775 949 1146 912 1442 244 314 1239 1044 280 1426